The objective of this study was to determine the effect of therapeutic ivermectin on African trypanosomiasis
The continuing problem of human African trypanosomiasis
Most of the reported cases of West African Trypanosomiasis
are found in Central Africa (Democratic Republic of Congo, Angola, Sudan, Central Africa Republic, Chad, and Northern Uganda).
Accelera carries out preclinical development activities for molecules targeting various different therapeutic classes, including collaborations aimed at defining therapeutic solutions for other "neglected diseases," such as malaria, visceral leishmaniasis, African trypanosomiasis
, and Chagas' disease.
Since no trypanosomes were isolated from inoculated mice the diagnosis of West African trypanosomiasis
(WAT) was made.
ATLANTA -- The approval of the cosmetic formulation of eflornithine encouraged the reintroductions of its intravenous formulation and of nifurtimox, both used to treat African trypanosomiasis
In addition, DB-289 is a potential drug to treat African Trypanosomiasis
(sleeping sickness), an infectious disease that affects millions of people in underdeveloped countries.
We have discovered three other compounds that we have out-licensed for further development -- two compounds for the treatment of animal health indications that are licensed to Eli Lilly and Company and AN5568, also referred to as SCYX-7158, for human African trypanosomiasis
(HAT, or sleeping sickness), which is licensed to Drugs for Neglected Diseases initiative, or DNDi.
DNDi s primary objective is to deliver 11 to 13 new treatments by 2018 for leishmaniasis, human African trypanosomiasis
(sleeping sickness), Chagas disease, malaria, paediatric HIV, and specific helminth infections and to establish a strong R&D portfolio that addresses patients treatment needs and supports long term objectives.
NTDs designated by WHO for control or elimination: Buruli ulcer, Chagas disease, cysticercosis/taeniasis, dengue / severe dengue, dracunculiasis (guinea-worm disease), echinococcosis, food-borne trematodiases, human African trypanosomiasis
, the leishmaniases, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthiases, trachoma, and yaws.
NTDs designated by the WHO for control or elimination: Buruli ulcer, Chagas disease (American trypanosomiasis), cysticercosis / taeniasis, dengue / severe dengue, dracunculiasis (Guinea worm disease), echinococcosis, fascioliasis, human African trypanosomiasis
, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthiasis, trachoma, and yaws.
Previous reports on trypanosomiasis showed that Benue state was a known human African trypanosomiasis
(HAT)/sleeping sickness endemic focus (4,5).
We describe a British safari tourist with multi-organ dysfunction and shock secondary to African trypanosomiasis
Sleeping sickness, or human African trypanosomiasis
(HAT), is a neglected tropical disease of major importance.
More than 66 million people in 36 countries of sub-Saharan Africa suffer from human African trypanosomiasis
, which is caused by either T.