A hybrid between genetic algorithms and artificial immune system method has been proposed that takes into account the main immune aspects: selection and cloning of the most stimulated cells, death of non- stimulated cells, affinity maturation
and re-selection of the clones with higher affinity, generation and maintenance of diversity, hypermutation proportional to the cell affinity.
of phage display antibody populations using ribosome display.
In addition, in the past nine months, customers have ordered over $750,000 of custom services including antigen design, novel antibody discovery and development, and affinity maturation
of existing antibodies.
Their activity may rely either on molecular excess or on affinity maturation
during vaccination (28).
Second, yeast display offers a faster and less labor-intensive path for optimizing a molecule of interest through affinity maturation
Entitled "An integrated approach to extreme thermostabilization and affinity maturation
of an antibody", Dr.
Antibody Engineering: Humanization, Affinity Maturation
, and Selection Techniques (Juan C.
Researchers at Xencor applied the company's proprietary humanization and affinity maturation
technologies to decrease the immunogenicity of XmAb5574 and to increase both its affinity and stability.