Blood enters the glomerulus through the afferent arteriole
and exits via the efferent arteriole.
Uncomplicated vascular immune complex deposits consist of a deposition of immunoglobulins and complement primarily in afferent arterioles.
The walls of afferent arterioles were effaced by smudgy eosinophilic material that severely narrowed the vessel lumens, and nuclear pyknosis and karyorrhexis were seen within the altered arteriolar walls (Figure 1).
Rolofylline increases renal blood flow and urine production by blocking adenosine-mediated vasoconstriction of the afferent arterioles
of the kidneys and inhibiting salt and water reabsorption by the kidney.
Dilation of the afferent arterioles
(due to ischaemic injury) causes glomerular hypertension, hyperfiltration and damage to the glomerulus and its basement membrane.