The E4 region of human adenoviruses
encodes a set of proteins that can regulate early gene expression for viral RNA export and stabilization (21,25).
Crystal's and Wilson's teams will spray up to four teaspoons of CFTR-containing adenoviruses
into the patients' nasal passages and, later, directly into their lungs.
Identification of subgenus C adenoviruses
by fiber-based multiplex PCR.
In their experiments, the researchers spliced a gene for human alpha 1-antitrypsin -- a protein deficient in some emphysema patients -- into adenoviruses
that were incapable of reproducing to cause disease.
The Rb patent, coupled with the p53 patent we received in October of last year, provides critical protection for our leading position as developers of modified adenoviruses
for the treatment of cancer," said Hollings Renton, president and chief executive officer of Onyx.
Investigators speculated that immunity to Ad35 may have waned in the long-term residents, who may have been less likely to have been exposed to adenoviruses
circulating in the community.
The patent specifically covers the use of modified adenoviruses
and other DNA viruses, which lack viral proteins that bind to the tumor suppressor protein p53, to treat cancer patients whose tumors lack p53 function.
and picomaviruses can cause AHC outbreaks (1).
attached the major surface antigen of the hepatitis B virus to adenoviruses
, which normally infect human lungs but can also grow in the gut.
are relatively benign viruses that occur widely in the human population and cause only mild, self-limiting infections.
(Ads) comprise 51 serotypes (1); they are ubiquitous and responsible for a wide range of clinical syndromes.
Our results demonstrate the potentialutility of recombinant adenoviruses
as live oral vaccines,' the authors conclude.
10, 1996--ONYX Pharmaceuticals announced today the receipt of a notice of allowance for a United States patent covering the use of modified adenoviruses
that selectively kill cancer cells exhibiting p53 mutations while leaving normal cells unaffected.
were isolated on human lung carcinoma (A-549) cells.
were isolated in human lung carcinoma (A-549) cells (Viromed Laboratories, Inc.