Scientists of the Helmholtz Centre for Infection Research (HZI) in Germany investigated the different versions protein called actin found in Plasmodium parasite, which causes malaria.
The researchers have succeeded in detecting filament assembly of the parasite actin II proteins.
He said that they have discovered that Plasmodium actin filaments are very different from other actin filaments and now that they know the structural basis for this, we can look for ways to specifically interfere with the parasite cytoskeleton to the of this protein in the parasite in high detail.
One of the intriguing properties of Gc-globulin is its ability to bind extracellular actin released by necrotic cell destruction into the circulation and, thus, to protect against disseminated intravascular coagulation induced by polymerized forms of actin (2).
Other clinical situations such as septic conditions have also been shown to be associated with low Gc-globulin concentrations and actin complexation (16), but the specific role of Gc-globulin has yet to be defined.
Immunohistochemical staining was positive for both smooth muscle actin
and muscle-specific actin
(HHF-35), but negative for cytokeratin (figure 3).