For both ALL and ANLL
, the relationship was observed for the indicators of proximity or density of main roads and of [NO.
In CML patients 8q13 has been reported in translocations other than Ph and 4q 11 was reported in association with ANLL
(8), (18), (20).
In that review, IARC determined for the first time that in addition to the confirmed association with ANLL
, there was also limited evidence that benzene causes acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM) in humans (Baan et al.
This new filing is based primarily on the results of a Phase III, randomized, placebo-controlled study of Leukine in 124 adults with ANLL
that were presented in December 1993 at the American Society of Hematology meeting.
Among the leukemias, 1,938 were ALL and 368 were ANLL