Angioedema is a potentially life-threatening adverse effect of ACE inhibitors
, with a reported incidence of 0.
While ACE inhibitors
decrease the 'bad' enzymes, our intent was to be the first team to design a drug that not only decreases the bad but simultaneously increases the good.
The researchers also assessed the impact of ACE inhibitors
on the brain power of 30 patients newly prescribed these drugs, during their first six months of treatment.
A retrospective analysis of longitudinal data from the prospective Health ABC (Dynamics of Health, Aging and Body Composition Study) found that femoral neck bone mineral density was significantly greater in elderly men on an ACE inhibitor
for 5 or more years for treatment of hypertension than in those not on long-term ACE inhibitor
Besides administering ACE inhibitors
at night, the study also suggests that doctors should consider using short-acting versions of the drug.
A 2004 retrospective cohort study evaluating risk factors for adverse drug events associated with ACE inhibitors
found factors such as hyperkalemia and renal impairment to be reasons for discontinuation of the medication.
It is thought that some ACE inhibitors
protect from dementia and mental decline by decreasing oxidative stress and inflammation in the brain, she noted.
This means that ACE inhibitors
can be used to improve the symptoms of heart failure, where the heart is not pumping as efficiently, and to improve survival following a heart attack.
In this issue of the Journal, Kanbay et al add to the accumulating evidence of association between pancreatitis and ACE inhibitors
Babies exposed in the first trimester of their mother's pregnancy to blood pressure drugs called ACE inhibitors
are at an increased risk of birth defects, according to a new study.
The use of ACE inhibitors
in the first trimester has been linked to an array of congenital malformations of the fetal cardiovascular system, CNS, and renal system, and therefore can no longer be considered safe, according to an observational study involving more than 29,000 pregnancies conducted by Dr.
Enalapril was superior to the isosorbidc nitrate/hydralazine combination for prolonging survival, and ACE inhibitors
subsequently became the primary treatment for heart failure.
A review of data from the Centers for Medicare and Medicaid Services' National Heart Care Project showed that 32 percent of elderly heart failure patients were discharged from hospitals without prescriptions for ACE inhibitors
to validate current guideline recommendations that all patients with systolic dysfunction should be getting ACE inhibitors
, unless they have a contraindication to the use of these drugs.
Until now there's been nothing to give these patients who couldn't take Ace inhibitors
and have missed out on the benefits.