thioguanine

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  • noun

Words related to thioguanine

an antineoplastic drug used to treat acute leukemias

References in periodicals archive ?
5] Nonstandard abbreviations: AZA, azathioprine; 6-MP, 6-mercaptopurine; 6-TGN, 6-thioguanine nucleotide; 6-MMPR, 6-methylmercaptopurine ribonucleotide; TPMT, thiopurine S-methyltransferase; TNF-[alpha], tumor necrosis factor-[alpha]; IBD, inflammatory bowel disease; XO, xanthine oxidase; HPRT, hypoxanthineguanine phosphoribosyltransferase; 6-MMP, 6-methylmercaptopurine; 5-ASA, 5-aminosalicylic acid.
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active Crohn disease: results from a randomized, controlled, open trial.
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease.
The American College of Gastroenterology honored the Cleveland Clinic Foundation with the "ACG Governors Award for Excellence in Clinical Research in 2000" for its study of 6-Thioguanine (6-TG) levels versus White Blood Counts (WBC) in guiding 6-Mercaptopurine and azathioprine therapy in adults.
TPMT assay methodology is poorly standardized, but our results should apply equally to the respective cutoff activities of other assays; for example, when 6-thioguanine is used as substrate.
6-MP is activated to 6-thioinosine monophosphate (6-TIMP) and subsequently to 6-thioguanine (6-TG) nucleotides (6-TGNs) by a multistep process involving several enzymes of the purine salvage pathway (2).
Reagents and media for cell culture were obtained from the following suppliers: 6-thioguanine (TG), citric acid, and dimethyl sulfoxide (DMSO) were obtained from Sigma (St.
Although the physiologic function of the enzyme is still unknown, TPMT is involved in the metabolism of the thiopurine drugs 6-mercaptopurine, 6-thioguanine, and azathioprine.
The thiopurines 6-mercaptopurine (Purinethol[R]), azathioprine (Imurel[R]), and 6-thioguanine (Lanvis[R]) are used in the treatment of leukemia and inflammatory bowel disease (IBD) (4) and to prevent organ transplant rejection (1-3).
The enzyme catalyzes the S-methylation of these medicinal agents, a metabolic pathway that competes with the formation of pharmacologically active 6-thioguanine nucleotides (6-TGNs), thereby modulating their therapeutic and toxic effects (1,2).
In fact, lacI does not require in vivo expression, whereas the resistant 6-thioguanine phenotype ([hprt.
We eventually obtained a small sample of 6-thioguanosine 5'-monophosphate, from what was then Burroughs Wellcome, and confirmed the time and conditions of the acid hydrolysis to 6-thioguanine (6).
Thiopurine drugs [6-mercaptopurine, 6-thioguanine (6-TG), [1] and azathioprine] are widely used in both the treatment of acute lymphoblastic leukemia and autoimmune disorders and in immunosuppressive regimens for the prevention of acute rejection after solid organ transplantation.
Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy.
Thiopurine S-methyltransferase (TPMT) [1] is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds such as 6-mercaptopurine, 6-thioguanine, and azathioprine, collectively termed thiopurines.