It is likely that exposure to corticosteroids, 6-mercaptopurine
, and subsequently infliximab increased the patient's immunosuppression and susceptibility to infection.
The thiopurine antimetabolites azathioprine and 6-mercaptopurine
are commonly used to treat inflammatory bowel disease; however, their administration at conventional doses is associated with adverse events and a lack of response in some patients.
Myelosuppression: Patients receiving 6-mercaptopurine
and methotrexate during maintenance are at risk for myleosuppression, which can be managed with dose delays and adjustments, depending on severity.
14,15) Several cytostatic agents incorporated in the front-line treatment of ALL have been shown to increase the incidence of secondary hematological malignancies: epipodophyllotoxins, alkylating agents, antracyclines and 6-mercaptopurine
KEY WORDS: azathioprine, thiopurine methyltransferase, thioguanine, 6-mercaptopurine
Since the synthesis of the first thiopurine drug, 6-mercaptopurine
, by Elion in 1951 (20), numerous HPLC procedures have been reported.
Two randomized trials showed that there was no benefit in using 6-mercaptopurine
, mesalamine, or azathioprine to prevent the postoperative recurrence of Crohn's disease, said Dr.
Identification of 6-methylmercaptopurine ribonucleoside 5'-diphosphate and 5'-triphosphate as metabolites of 6-mercaptopurine
A suspension will allow more flexibility in adjusting the dose" and that "a commercially produced suspension is more likely to provide a more consistent dose of 6-mercaptopurine
than ad hoc compounded formulations.
Mesalamine may increase the risk of blood disorders when used with azathioprine and 6-mercaptopurine
BALTIMORE--Combination therapy with either 6-mercaptopurine
or azathioprine plus cyclosporine may help patients with severe ulcerative colitis avoid colectomies for at least 12 years, Dr.
(6-MP; 10 [micro]L; final concentration, 4 mmol/L) was added to 300 [micro]L of red cell lysates containing 100 [micro]L of 0.
Some of these cases occurred in young adult patients on concomitant treatment with azathioprine or 6-mercaptopurine
used for Crohn's disease.
Azathioprine and 6-mercaptopurine
should not be taken in the first trimester but can be used in the remainder of pregnancy if required.
Thiopurine S-methyltransferase (TPMT)  is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds such as 6-mercaptopurine
, 6-thioguanine, and azathioprine, collectively termed thiopurines.