fluorouracil

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  • noun

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an antimetabolite used to treat certain cancers

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Personalized dosing via pharmacokinetic (PK) monitoring of 5-Fluorouracil (5-FU) might reduce toxicity in early or late stage colorectal cancer patients treated with infusional 5-fluorouacil-based chemotherapy regimens.
Conventional chemotherapy of cancer with 5-fluorouracil (5-FU) in combination with other agents improves the overall and disease-free survival of patients after surgery (Machover 1997).
Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls.
We intend to market 5-fluorouracil under the Bigmar label," said John G.
Food & Drug Administration (FDA) has granted FUSILEV([R]) (levoleucovorin) "Orphan Drug" exclusivity for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer.
The current study utilized cultures of two high density colorectal cell lines that were sensitive to 5-fluorouracil and cultures of their 5-FU resistant clones.
Saladax's first commercially available test for innovative dose management; My5-FU measures levels of 5-fluorouracil (5-FU), a widely used chemotherapy drug used in conjunction with other drugs in first-line therapy for colorectal cancer and other solid tumors.
Secondly, the influence of bisabololoxide A on antiproliferative action of 5-fluorouracil, one of successful anticancer agents (Diasio and Harris 1989; Longley et al.
Today, patients such as the woman described above are clearly regarded as having a chance of curative treatment; however, it may be worth remembering that this patient would have had a very poor prognosis in the era of 5-fluorouracil (5FU) monotherapy when, according to a prognostic model, life expectancy would have been only 6 months [2] and liver resections were rare [3].
There is one case on cisplatin induced localized aortic thrombus and one case about transient intracardiac thrombus after 5-fluorouracil therapy on the literature (4, 5).
This is the first time that patients with advanced colorectal cancer have received both bevacizumab, a humanized monoclonal antibody that binds to and inhibits vascular endothelial growth factor, and the chemotherapy combination known as FOLFOX4, which is oxaliplatin, 5-fluorouracil, and leucovorin.
DPD is also the principal enzyme involved in detoxification of pyrimidine-based antimetabolic analogs, such as 5-fluorouracil (5-FU), a drug that is commonly used in the treatment of solid tumors (colon, breast, head, neck, ovary, and skin).
They randomly assigned patients to a group receiving no further treatment after surgery or to groups receiving additional treatment -- either a veterinary drug known as levamisole or a combination of levamisole and 5-fluorouracil, a federally approved anticancer drug.
announced today that an international Phase III study demonstrated that oral Xeloda([R]) plus oxaliplatin (XELOX) is superior to a commonly used intravenous chemotherapy, 5-FU/LV (infused 5-fluorouracil plus leucovorin), in increasing the time people with adjuvant colon cancer lived without their cancer returning when given immediately after surgery.