reductase

(redirected from 5-alpha reductase)
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  • noun

Words related to reductase

an enzyme that catalyses the biochemical reduction of some specified substance

References in periodicals archive ?
It has been shown in studies of obese patients--both male and female --that 5-alpha reductase levels rise in response to the development of insulin resistance and that the rise in the 5-alpha reductase levels is associated with inactivation of cortisol levels in the liver.
To our knowledge, studies examining the efficacy and the adverse effects of the combination therapy of PDE-5 inhibitors with 5-alpha reductase inhibitors have not yet been published.
Another virtue to using 5-alpha reductase inhibitors (like Avodart[R] or Proscar[R]) is that in the presence of prostate cancer, PSA levels don't decrease as much after these drugs are initiated.
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibennzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose dependent increase of mRNA levels of 5-alpha reductase type 2 in contrast to decrease of androgen receptor in pubertal ventral prostate.
Jean Wilson's discovery of the role of the enzyme 5-alpha reductase in BPH.
Screenings showed that oleanoic acid (OA) derived from olive tree leaves inhibits 5-alpha reductase type I activity, which influences testosterone levels and hyperseborrhea.
The treatment works by stopping the action of an enzyme called 5-alpha reductase which converts male testosterone into DHT, a hormone that triggers the hair loss process in men.
The mechanism of action of finasteride is to inhibit the steroid 5-alpha reductase, which is an intracellular enzyme that converts testosterone into the potent androgen 5-alpha dihydrotestosterone (DHT).
Made primarily in the prostate, this enzyme, 5-alpha reductase type II, converts testosterone to dihydrotestosterone (DHT).
Drugs such as botulinum toxins, retinoids, acid peels, 5-alpha reductase and lipase inhibitors associated with cutaneous ageing, photodamage, pigmentation defects, alopecia, and the lipodermal disorders of obesity and gynoid lipodystrophy are critically discussed to provide a detailed analysis of the high-growth market sector estimated at US$1.
To understand the role of 5-alpha reductase inhibitors (5ARIs) (e.
Anageline shows a significant inhibiting effect (-18%) on the activity of 5-alpha reductase II, an enzyme responsible for follicle miniaturization characteristic of androgenic alopecia.
However, the 5-alpha reductase inhibitor trials provided proof of principle that the risk of a subset of prostate cancer can be reduced by drugs.
3), (4) Both of these drugs inhibit the 5-alpha reductase enzyme, thus blocking the conversion of testosterone to much more powerful DHT.
For the technically inclined, finasteride is a 5-alpha reductase inhibitor.
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