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  • noun

Words related to fluorouracil

an antimetabolite used to treat certain cancers

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Easy access to the 5-FU PCM Assay will provide oncologists with a proven tool to improve treatment outcomes and a better quality of life for their cancer patients.
Unconfirmed objective response rate was higher in the ONIVYDE in combination with 5-FU and leucovorin arm than in the 5-FU and leucovorin arm: 16% (19/117) versus 1% (1/119) (difference 15.
The compelling results generated to date demonstrate that NUC-3373 has the potential to replace 5-FU as the standard of care for colorectal cancer and other solid tumours.
5-FU injection (250 mg/10 ml) was purchased from Xudong-haipu parmaceutical company, Shanghai, China; regents for western blot and RT-PCR were purchased from Bio-Rad, USA; P53, bcl-2, bax, bid and [beta]-actin antibodies, secondary antibodies were obtained from cell signaling, MA, USA.
Phase II trials evaluating oxaliplatin either alone or in combination with 5-FU in patients with colorectal cancer have appeared in the European literature since 1993.
The incidence of 5-FU overexposure is low though difficult to quantify.
Under the terms of the agreement, BTG will have exclusive rights to market, sell and distribute uridine triacetate as a treatment for 5-FU overexposure in the US for up to 10 years from marketing approval.
The results of such experimental and clinical studies showed that these agents could both significantly improve the effectiveness of 5-FU and reduce toxicity.
Colorectal cancer patients were treated with oxaliplatin plus 5-fluorouracil (5-FU), or weekly CPT-11 or 5-FU and folates (FA).
Presentation At ASCO Annual Meeting Will Report On Data For Uridine Triacetate To Reverse 5-FU Overexposure
CoFactor appears to offer a less toxic alternative to leucovorin with improved pharmacodynamics and anti-tumor activity in combination with 5-FU.
The kickoff meeting is being held this week to launch the Phase II clinical trial of DAVANAT([R])with Avastin([R]), 5-FU and leucovorin for front line therapy of patients with metastatic colorectal cancer.
The Company has been conducting clinical and pre-clinical studies with its lead product candidate, DAVANAT([R]), in combination with 5-FU, leucovorin, irinotecan, doxorubicin, oxaliplatin, paclitaxel, cisplatin and bevacizumab (AVASTIN([R])).
CoFactor plus 5-FU helped stabilize the overwhelming majority of these patients and did so with a minimum of serious hematological or gastrointestinal toxicity," commented Joan M.