Priority group 3: Established patients receiving d4T, 3TC
The instrument was set at 300, 285 and 270 nm for NVP, 3TC
and d4T respectively.
It has been shown that removal of 3TC
from a failing antiviral regimen leads to an average increase of 0.
When Reverset was used without other cytidine analogs, 3TC
and FTC, it was a very powerful drug against resistant virus.
Has an excellent safety profile at least equal to 3TC
We don't usually think of d4T, 3TC
, and Sustiva having a problem of bone loss.
The incidence of resistance to 3TC
was significantly lower (13 percent) in patients treated with 908/r who experienced treatment failure or had ongoing viral replication (4 of 32 subjects) than those treated with NFV (57 percent; 31 of 54).
The results "definitively proved that a combination of ZDV, 3TC
, and efavirenz is a very good starting regimen.
It is combined with the standard AIDS medicines AZT and 3TC
This was markedly better than those patients on the 3TC
Also, two three-drug regimens that doctors agree should never be used as the only antiretroviral treatment are tenofovir plus 3TC
plus abacavir, or tenofovir plus 3TC
plus ddl; these were unexpectedly found to cause serious drug resistance in many cases, including the K65R and MI84V/I mutations.
Both FTC-302 and FTC-303 were randomized, controlled trials comparing FTC (200 mg once daily) to 3TC
(150 mg twice daily) in triple therapy combination regimens.
Overall there were fewer adverse effects (AE's) in either ATC arm than in the 3TC
Last year two three-drug regimens that had once seemed reasonable (tenofovir + 3TC
+ abacavir; also tenofovir + 3TC
+ddI) were found to work very badly; these combinations must never be used alone as antiretroviral treatment, because they fail in most patients and cause serious drug resistance.
Marketed as Epivir and 3TC
, lamivudine is a nucleoside analogue reverse transcriptase inhibitor which was discovered by BioChem Pharma and approved by the U.